Sphingosine 1‐phosphate enhances tissue inhibitor of metalloproteinases (TIMPs) expression in human endothelial cells
نویسندگان
چکیده
منابع مشابه
Expression of Tissue Inhibitors of Metalloproteinases (TIMPs) in Hepatocellular Carcinoma
BACKGROUND Matrix metalloproteinases (MMPs) have been implicated in the remodelling of extracellular matrix (ECM), including basement membrane. ECM remodelling is associated with pathological processes, including hepatic fibrosis, tumor invasion and metastasis. Tissue inhibitors of metalloproteinase (TIMP)-1 and TIMP-2 were known to inhibit MMP-9 and MMP-2, respectively. In the present study, w...
متن کاملElevated levels of tissue inhibitor of metalloproteinases (TIMPS) in human hepatocellular carcinomas
Email: Eiji Matsumoto* [email protected]; Harushige Nakatsukasa [email protected]; Kazuhiro Nouso [email protected]; Shin-ichiro Nakamura [email protected]; Mayumi Suzuki [email protected]; Yoshiyuki Kobayashi [email protected]; Masayuki Uemura [email protected]; Syuichiro Sato [email protected]; Eiichiro Yumoto [email protected]; Junko Yokoyama agkun@...
متن کاملExpression of tissue inhibitor of metalloproteinases (TIMPs) during early cardiac development
Matrix metalloproteinases (MMPs) mediate cell migration and tissue remodeling and are important in cardiac development. We examined the expression patterns of two MMP inhibitors, tissue inhibitor of metalloproteinase (TIMP)-2 and TIMP-3, during critical stages of cardiac development. Both TIMP-2 and TIMP-3 mRNA were expressed in the endocardium prior to and during early cushion cell formation. ...
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Increased production of matrix metalloproteinases (MMPs) has been associated with increases in invasive and metastatic potential in many types of human carcinoma. Tissue inhibitors of metalloproteinase (TIMP)-1 inhibits most interstitial collagenases and MMP-9. TIMP-2 binds specifically and noncovalently to the pro-form of MMP-2 and inhibits its enzyme activity. In this study, we examined TIMP-...
متن کاملMetalloproteinases and tissue inhibitor of metalloproteinases in mesothelial cells. Cellular differentiation influences expression.
Mesothelial cells play a critical role in the remodeling process that follows serosal injury. Although mesothelial cells are known to synthesize a variety of extracellular matrix components including types I, III, and IV collagens, their potential to participate in matrix degradation has not been explored. We now report that human pleural and peritoneal mesothelial cells express interstitial co...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.4.a750